Protein Name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
|
UniprotKB/SwissProt ID: P31230 (P31230)
Gene Name:
Aimp1
Organism: Mus musculus (Mouse)
Function: Non-catalytic component of the multisynthase complex (PubMed:12060739). Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (By similarity). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:1400342, PubMed:7545917). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (PubMed:18448069). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (PubMed:17001013). Promotes dermal fibroblast proliferation and wound repair (PubMed:15681823). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (PubMed:17525271). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (By similarity). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:18292511). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, cytosol. Secreted. Endoplasmic reticulum. Golgi apparatus
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P31230
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
159 |
DASRLDLRIG C IVTAKKHPDA |
CCCHHHHHHH H HHCCCCHHHH |
1.79% |
20925432
21278135
|
|
