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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: S-adenosylmethionine synthase isoform type-2

UniprotKB/SwissProt ID: P31153 (P31153)

Gene Name: MAT2A

Organism: Homo sapiens (Human)

Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR022631 ADOMET_SYNTHASE_CS
IPR022630 S-AdoMet_synt_C
IPR022629 S-AdoMet_synt_central
IPR022628 S-AdoMet_synt_N
IPR002133 S-AdoMet_synthetase
IPR022636 S-AdoMet_synthetase_sfam

The S-nitrosylation sites of P31153

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 104 DSSKGFDYKT C NVLVALEQQS   
2 149 FGYATDETEE C MPLTIVLAHK   
3 214 VISVQHDEEV C LDEMRDALKE   
4 34 SVGEGHPDKI C DQISDAVLDA   
5 56 LQQDPDAKVA C ETVAKTGMIL