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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Rab GDP dissociation inhibitor alpha

UniprotKB/SwissProt ID: P31150 (P31150)

Gene Name: GDI1

Organism: Homo sapiens (Human)

Function: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Golgi apparatus, trans-Golgi network

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI

The S-nitrosylation sites of P31150

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 202 YRTDDYLDQP C LETVNRIKLY  CCCCCEEEEE C CCHHHHHHHC  4.45%
2 277 GVKSEGEVAR C KQLICDPSYI  CCCCCEEEEE C CCHHHHHHHC  2.07% 37478858
3 282 GEVARCKQLI C DPSYIPDRVR  CCCCCEEEEE C CCHHHHHHHC  9.52% 37478858
4 317 PIKNTNDANS C QIIIPQNQVN  CCCCCEEEEE C CCHHHHHHHC  3.19% 2212679
5 335 QVNRKSDIYV C MISYAHNVAA  CCCCCEEEEE C CCHHHHHHHC  0.82% 37478858