Protein Name:
Catenin delta-1
|
UniprotKB/SwissProt ID: P30999 (P30999)
Gene Name:
Ctnnd1
Organism: Mus musculus (Mouse)
Function: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:33972531). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, adherens junction. Cytoplasm. Nucleus. Cell membrane. Cell junction. Nucleus
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P30999
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
394 |
SNAAAYLQHL C YRNDKVKTDV |
CCHHHHHHHH H HHHHHHHHHH |
2.55% |
20925432
|
| 2 |
429 |
HPKKEVHLGA C GALKNISFGR |
CCHHHHHHHH H HHHHHHHHHH |
2.88% |
20925432
|
| 3 |
450 |
DQDNKIAIKN C DGVPALVRLL |
CCHHHHHHHH H HHHHHHHHHH |
4.01% |
21278135
|
| 4 |
533 |
WESVLTNTAG C LRNVSSERSE |
CCHHHHHHHH H HHHHHHHHHH |
2.75% |
20925432
|
| 5 |
692 |
EASAGAIQNL C AGRWTYGRYI |
CCHHHHHHHH H HHHHHHHHHH |
5.04% |
|
|
