Protein Name:
Peptidyl-prolyl cis-trans isomerase FKBP4
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UniprotKB/SwissProt ID: P30416 (P30416)
Gene Name:
Fkbp4
Organism: Mus musculus (Mouse)
Function: Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P30416
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
103 |
AVATMKVGEV C HITCKPEYAY |
CCHHHHHHHH C CCCCCCCCCC |
1.35% |
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| 2 |
328 |
RLASHLNLAM C HLKLQAFSAA |
CCHHHHHHHH C CCCCCCCCCC |
2.57% |
21278135
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| 3 |
342 |
LQAFSAAIES C NKALELDSNN |
CCHHHHHHHH C CCCCCCCCCC |
3.82% |
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| 4 |
396 |
NKAAKTQLAV C QQRTRRQLAR |
CCHHHHHHHH C CCCCCCCCCC |
2.07% |
20925432
21278135
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