Protein Name:
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
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UniprotKB/SwissProt ID: P30405 (P30405)
Gene Name:
PPIF
Organism: Homo sapiens (Human)
Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P30405
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
104 |
TFHRVIPSFM C QAGDFTNHNG |
CCEEECCCEE E ECCCCCCCCC |
2.06% |
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| 2 |
157 |
PNTNGSQFFI C TIKTDWLDGK |
CCEEECCCEE E ECCCCCCCCC |
2.45% |
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| 3 |
203 |
RTSKKIVITD C GQLS------ |
CCEEECCCEE E ECCCCCCCCC |
2.54% |
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