Protein Name:
Protein disulfide-isomerase A3
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UniprotKB/SwissProt ID: P30101 (P30101)
Gene Name:
PDIA3
Organism: Homo sapiens (Human)
Function: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone (PubMed:11825568, PubMed:16193070, PubMed:27897272, PubMed:36104323, PubMed:7487104). Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity (PubMed:35948544, PubMed:36104323)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P30101
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
244 |
KFIQENIFGI C PHMTEDNKDL |
CCHHHHHCHH H HHHHHHHHHH |
1.61% |
20140087
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| 2 |
85 |
KGIVPLAKVD C TANTNTCNKY |
CCHHHHHCHH H HHHHHHHHHH |
4.3% |
2212679
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| 3 |
92 |
KVDCTANTNT C NKYGVSGYPT |
CCHHHHHCHH H HHHHHHHHHH |
4.48% |
2212679
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