Protein Name:
Enoyl-CoA hydratase, mitochondrial
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UniprotKB/SwissProt ID: P30084 (P30084)
Gene Name:
ECHS1
Organism: Homo sapiens (Human)
Function: Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:26251176). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA) (PubMed:26251176). Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (PubMed:26251176). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:25125611, PubMed:26251176). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P30084
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
111 |
KEMQNLSFQD C YSSKFLKHWD |
CHHHHHHHHH H CCCCCCCCCC |
2.17% |
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| 2 |
213 |
AKQAGLVSKI C PVETLVEEAI |
CHHHHHHHHH H CCCCCCCCCC |
3.38% |
22178444
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| 3 |
225 |
VETLVEEAIQ C AEKIASNSKI |
CHHHHHHHHH H CCCCCCCCCC |
4.28% |
22178444
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| 4 |
62 |
LNRPKALNAL C DGLIDELNQA |
CHHHHHHHHH H CCCCCCCCCC |
3.47% |
25040305
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