Protein Name:
Thioredoxin-dependent peroxide reductase, mitochondrial
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UniprotKB/SwissProt ID: P30048 (P30048)
Gene Name:
PRDX3
Organism: Homo sapiens (Human)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMed:29438714, PubMed:33889951, PubMed:7733872). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cytoplasm. Early endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P30048
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
229 |
FQYVETHGEV C PANWTPDSPT |
CHHHHHHHHH H HHHHHHCCCC |
1.99% |
22178444
18335467
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