Protein Name:
Peroxiredoxin-6
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UniprotKB/SwissProt ID: P30041 (P30041)
Gene Name:
PRDX6
Organism: Homo sapiens (Human)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Lysosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P30041
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
47 |
FSHPRDFTPV C TTELGRAAKL |
CCCCEEECCC C CCCCCCCCEE |
4.03% |
25040305
2212679
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| 2 |
91 |
AWSKDINAYN C EEPTEKLPFP |
CCCCEEECCC C CCCCCCCCEE |
4% |
19483679
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