Protein Name:
Vascular cell adhesion protein 1
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UniprotKB/SwissProt ID: P29533 (P29533)
Gene Name:
Vcam1
Organism: Mus musculus (Mouse)
Function: Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P29533
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
668 |
AQLQDAGIYE C ESKTEVGSQL |
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