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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Nitric oxide synthase 3
UniprotKB/SwissProt ID: P29474 (P29474)

Gene Name: NOS3

Organism: Homo sapiens (Human)

Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR003097 CysJ-like_FAD-binding
IPR017927 FAD-bd_FR_type
IPR001094 Flavdoxin-like
IPR008254 Flavodoxin/NO_synth
IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR029039 Flavoprotein-like_sf
IPR039261 FNR_nucleotide-bd
IPR023173 NADPH_Cyt_P450_Rdtase_alpha
IPR050607 NOS
IPR044943 NOS_dom_1
IPR044940 NOS_dom_2
IPR044944 NOS_dom_3
IPR012144 NOS_euk
IPR004030 NOS_N
IPR036119 NOS_N_sf
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
The S-nitrosylation sites of P29474
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1048 QPTPMTLVFG C RCSQLDHLYR  CCCHHHHCCC C CCCCCCCCCC  2.42% 22178444
17941803
2 1050 TPMTLVFGCR C SQLDHLYRDE  CCCHHHHCCC C CCCCCCCCCC  3.37% 22178444
17941803
3 1114 LCLERGHMFV C GDVTMATNVL  CCCHHHHCCC C CCCCCCCCCC  2.35% 22178444
17941803
4 184 AKQAWRNAPR C VGRIQWGKLQ  CCCHHHHCCC C CCCCCCCCCC  3.56% 22178444
16081307
5 201 GKLQVFDARD C RSAQEMFTYI  CCCHHHHCCC C CCCCCCCCCC  2.85% 22178444
16081307
6 212 RSAQEMFTYI C NHIKYATNRG  CCCHHHHCCC C CCCCCCCCCC  1.82% 22178444
16081307
7 661 GLGSRAYPHF C AFARAVDTRL  CCCHHHHCCC C CCCCCCCCCC  2.5% 22178444
17941803
8 802 QYQPGDHIGV C PPNRPGLVEA  CCCHHHHCCC C CCCCCCCCCC  3.8% 22178444
17941803
9 853 GWVRDPRLPP C TLRQALTFFL  CCCHHHHCCC C CCCCCCCCCC  5.45% 22178444
17941803
10 94 LSAQAQQDGP C TPRRCLGSLV  CCCHHHHCCC C CCCCCCCCCC  11.35% 22178444
15774480
17941803
11 976 DGLGPLHYGV C STWLSQLKPG  CCCHHHHCCC C CCCCCCCCCC  2.32% 22178444
17941803
12 99 QQDGPCTPRR C LGSLVFPRKL  CCCHHHHCCC C CCCCCCCCCC  5.5% 22178444
16081307
17941803
13 991 SQLKPGDPVP C FIRGAPSFRL  CCCHHHHCCC C CCCCCCCCCC  4.51% 22178444
17941803