Protein Name:
Synaptotagmin-2
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UniprotKB/SwissProt ID: P29101 (P29101)
Gene Name:
Syt2
Organism: Rattus norvegicus (Rat)
Function: Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed:17167421). The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed:15123599) (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); unlike the case with BoNT/B interaction is not improved in the presence of gangliosides (PubMed:15123599). The toxin binds to the vesicular domain of Syt2 (residues 1-61) (PubMed:15123599)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P29101
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
293 |
YVPTAGKLTV C ILEAKNLKKM |
CCCCCCCCCC C CCCCCCCCCC |
2.18% |
22178444
16418269
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