Protein Name:
Cytosol aminopeptidase
|
UniprotKB/SwissProt ID: P28838 (P28838)
Gene Name:
LAP3
Organism: Homo sapiens (Human)
Function: Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P28838
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
ENIRAAVAAG C RQIQDLELSS |
|
|
|
| 2 |
145 |
LELSSVEVDP C GDAQAAAEGA |
|
|
|
| 3 |
313 |
RADMGGAATI C SAIVSAAKLN |
|
|
|
| 4 |
335 |
PINIIGLAPL C ENMPSGKANK |
|
|
|
| 5 |
376 |
EGRLILADAL C YAHTFNPKVI |
|
|
|
| 6 |
445 |
FEHYTRQVVD C QLADVNNIGK |
|
|
|
| 7 |
462 |
NIGKYRSAGA C TAAAFLKEFV |
|
|
|
|
