UniprotKB/SwissProt ID: P28799 (P28799)
Gene Name:
GRN
Organism: Homo sapiens (Human)
Function: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12526812, PubMed:18378771, PubMed:28073925, PubMed:28453791, PubMed:28541286). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771) Promotes proliferation of the epithelial cell line A431 in culture Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8 Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Lysosome
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