UniprotKB/SwissProt ID: P28798 (P28798)
Gene Name:
Grn
Organism: Mus musculus (Mouse)
Function: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12524533, PubMed:20026663, PubMed:23041626, PubMed:27789271, PubMed:28073925, PubMed:28453791, PubMed:28541286, PubMed:8496151). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:27789271, PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (PubMed:12524533). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:8496151). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:20026663, PubMed:23041626) Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8 Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Lysosome
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