UniprotKB/SwissProt ID: P28661 (P28661)
Gene Name:
Septin4
Organism: Mus musculus (Mouse)
Function: Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (PubMed:30389919). May also play a role in the regulation of cell fate in the intestine (PubMed:30389919). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (PubMed:20952537). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (PubMed:23788729). Plays an important role in male fertility and sperm motility (PubMed:15737930, PubMed:15737931). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (PubMed:15737930, PubMed:15737931). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (PubMed:20181826). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (PubMed:17296554)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell projection, dendrite. Perikaryon. Synapse. Cytoplasm. Mitochondrion. Cytoplasm, cytosol
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