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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Adenylosuccinate synthetase isozyme 1

UniprotKB/SwissProt ID: P28650 (P28650)

Gene Name: Adss1

Organism: Mus musculus (Mouse)

Function: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR018220 Adenylosuccin_syn_GTP-bd
IPR033128 Adenylosuccin_syn_Lys_AS
IPR042109 Adenylosuccinate_synth_dom1
IPR042110 Adenylosuccinate_synth_dom2
IPR042111 Adenylosuccinate_synth_dom3
IPR001114 Adenylosuccinate_synthetase
IPR027509 AdSS_1_vert
IPR027417 P-loop_NTPase

The S-nitrosylation sites of P28650

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 183 SKAARTGLRI C DLLSDFDEFS  CCCCCCCCCC C CCCCCCCCCC  2.14% 21278135
2 63 LATDADIVSR C QGGNNAGHTV  CCCCCCCCCC C CCCCCCCCCC  3.25%