UniprotKB/SwissProt ID: P28474 (P28474)
Gene Name:
Adh5
Organism: Mus musculus (Mouse)
Function: Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (By similarity). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (By similarity). Class-III ADH is remarkably ineffective in oxidizing ethanol (By similarity). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (PubMed:11260719, PubMed:14980227)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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