UniprotKB/SwissProt ID: P28334 (P28334)
Gene Name:
Htr1b
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1557407, PubMed:17325130). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:1557407, PubMed:17325130). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (PubMed:10651141, PubMed:16750486, PubMed:8091214, PubMed:8742487, PubMed:9349547). Besides, plays a role in vasoconstriction of cerebral arteries (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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