Protein Name:
ATP-binding cassette sub-family D member 3
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UniprotKB/SwissProt ID: P28288 (P28288)
Gene Name:
ABCD3
Organism: Homo sapiens (Human)
Function: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation (PubMed:11248239, PubMed:24333844, PubMed:25168382, PubMed:29397936). Has fatty acyl-CoA thioesterase and ATPase activities (PubMed:29397936). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:24333844, PubMed:25944712)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Peroxisome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P28288
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
24 |
SLAGAAFLLL C LLHKRRRALG |
CCHHHHHHHH C CCHHHHHHHH |
3.71% |
37478858
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| 2 |
472 |
EVRSGANVLI C GPNGCGKSSL |
CCHHHHHHHH C CCHHHHHHHH |
6.92% |
2212679
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