UniprotKB/SwissProt ID: P28052 (P28052)
Gene Name:
gpa-3
Organism: Caenorhabditis elegans
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde-1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways (PubMed:19489741). Involved in behavioral response to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons (PubMed:25303524). Plays a role in the avoidance response to the noxious chemical quinine in ASH sensory neurons (PubMed:14988722)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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