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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Small ribosomal subunit protein uS5

UniprotKB/SwissProt ID: P27952 (P27952)

Gene Name: Rps2

Organism: Rattus norvegicus (Rat)

Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus, nucleolus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR020568 Ribosomal_Su5_D2-typ_SF
IPR000851 Ribosomal_uS5
IPR005324 Ribosomal_uS5_C
IPR005711 Ribosomal_uS5_euk/arc
IPR013810 Ribosomal_uS5_N
IPR018192 Ribosomal_uS5_N_CS
IPR014721 Ribsml_uS5_D2-typ_fold_subgr

The S-nitrosylation sites of P27952

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 188 HTVPCKVTGR C GSVLVRLIPA   
2 229 IDDCYTSARG C TATLGNFAKA