Protein Name:
Interleukin-1 receptor type 2
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UniprotKB/SwissProt ID: P27930 (P27930)
Gene Name:
IL1R2
Organism: Homo sapiens (Human)
Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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