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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Properdin
UniprotKB/SwissProt ID: P27918 (P27918)

Gene Name: CFP

Organism: Homo sapiens (Human)

Function: A positive regulator of the alternate pathway (AP) of complement (PubMed:16301317, PubMed:20382442, PubMed:28264884, PubMed:9748277). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:16301317, PubMed:20382442, PubMed:28264884, PubMed:9748277). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR049536 CFP_TSR-0
IPR054019 CFP_TSR_C
IPR052065 Compl_asym_regulator
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
The S-nitrosylation sites of P27918
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 376 DIRHCYSIQH C PLKGSWSEWS