Protein Name:
Calreticulin
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UniprotKB/SwissProt ID: P27797 (P27797)
Gene Name:
CALR
Organism: Homo sapiens (Human)
Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Cytolytic granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P27797
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
105 |
FTVKHEQNID C GGGYVKLFPN |
CCCHHHHHHH H HHHHHHCCCC |
4.9% |
25040305
2212679
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| 2 |
137 |
EYNIMFGPDI C GPGTKKVHVI |
CCCHHHHHHH H HHHHHHCCCC |
7.59% |
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| 3 |
163 |
KNVLINKDIR C KDDEFTHLYT |
CCCHHHHHHH H HHHHHHCCCC |
6.07% |
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