Protein Name:
Protein disulfide-isomerase A3
|
UniprotKB/SwissProt ID: P27773 (P27773)
Gene Name:
Pdia3
Organism: Mus musculus (Mouse)
Function: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P27773
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
244 |
KFIQDSIFGL C PHMTEDNKDL |
CCHHHHHCHH H HHHHHHHHHH |
1.91% |
22178444
|
| 2 |
85 |
KGIVPLAKVD C TANTNTCNKY |
CCHHHHHCHH H HHHHHHHHHH |
4.3% |
|
| 3 |
92 |
KVDCTANTNT C NKYGVSGYPT |
CCHHHHHCHH H HHHHHHHHHH |
4.48% |
|
|
