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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: CD59 glycoprotein

UniprotKB/SwissProt ID: P27274 (P27274)

Gene Name: Cd59

Organism: Rattus norvegicus (Rat)

Function: Potent inhibitor of the complement membrane attack complex (MAC) action, which protects self-cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Secreted

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR056949 CD59
IPR018363 CD59_antigen_CS
IPR050918 CNF-like_PLA2_Inhibitor
IPR016054 LY6_UPA_recep-like
IPR045860 Snake_toxin-like_sf

The S-nitrosylation sites of P27274

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 61 AVSGKQVYQQ C WRFSDCNAKF