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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Threonine--tRNA ligase 1, cytoplasmic
UniprotKB/SwissProt ID: P26639 (P26639)

Gene Name: TARS1

Organism: Homo sapiens (Human)

Function: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) (PubMed:25824639, PubMed:31374204). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR045864 aa-tRNA-synth_II/BPL/LPL
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR012675 Beta-grasp_dom_sf
IPR004095 TGS
IPR012676 TGS-like
IPR002320 Thr-tRNA-ligase_IIa
IPR018163 Thr/Ala-tRNA-synth_IIc_edit
IPR047246 ThrRS_anticodon
IPR033728 ThrRS_core
IPR012947 tRNA_SAD
The S-nitrosylation sites of P26639
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 107 SWKTTPYQIA C GISQGLADNT  CCCCCCCCCC C CCCCCCCCCC  5.48% 19483679
2 137 WDLDRPLEED C TLELLKFEDE  CCCCCCCCCC C CCCCCCCCCC  5.45%
3 237 LAMFKYNKFK C RILNEKVNTP  CCCCCCCCCC C CCCCCCCCCC  3.53%
4 254 VNTPTTTVYR C GPLIDLCRGP  CCCCCCCCCC C CCCCCCCCCC  3.45% 37478858
5 261 VYRCGPLIDL C RGPHVRHTGK  CCCCCCCCCC C CCCCCCCCCC  4.13% 37478858
6 343 YFFHELSPGS C FFLPKGAYIY  CCCCCCCCCC C CCCCCCCCCC  3.28%
7 467 RFQQDDAHIF C AMEQIEDEIK  CCCCCCCCCC C CCCCCCCCCC  3.31%
8 479 MEQIEDEIKG C LDFLRTVYSV  CCCCCCCCCC C CCCCCCCCCC  2.53%
9 558 IKDAIGRYHQ C ATIQLDFQLP  CCCCCCCCCC C CCCCCCCCCC  1.99%
10 630 QVMVVPVGPT C DEYAQKVRQQ  CCCCCCCCCC C CCCCCCCCCC  4.16%
11 656 FMADIDLDPG C TLNKKIRNAQ  CCCCCCCCCC C CCCCCCCCCC  4.81%