Protein Name:
Serine--tRNA ligase, cytoplasmic
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UniprotKB/SwissProt ID: P26638 (P26638)
Gene Name:
Sars1
Organism: Mus musculus (Mouse)
Function: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P26638
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
300 |
LPIKYAGLST C FRQEVGSHGR |
CCEECEEEEE C CCCCHHHHHH |
2.08% |
21278135
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| 2 |
395 |
GSGAFRELVS C SNCTDYQARR |
CCEECEEEEE C CCCCHHHHHH |
2.36% |
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