Protein Name:
Polypyrimidine tract-binding protein 1
|
UniprotKB/SwissProt ID: P26599 (P26599)
Gene Name:
PTBP1
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed:14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P26599
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
23 |
KRGSDELFST C VTNGPFIMSS |
CCCCCCCCCC C CCCCCCHHHH |
3.26% |
|
| 2 |
250 |
SLDGQNIYNA C CTLRIDFSKL |
CCCCCCCCCC C CCCCCCHHHH |
1.3% |
19483679
|
| 3 |
251 |
LDGQNIYNAC C TLRIDFSKLT |
CCCCCCCCCC C CCCCCCHHHH |
3.59% |
19483679
|
|
