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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutamate dehydrogenase 1, mitochondrial
UniprotKB/SwissProt ID: P26443 (P26443)

Gene Name: Glud1

Organism: Mus musculus (Mouse)

Function: Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate (PubMed:20670938). Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (PubMed:16959573). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion. Endoplasmic reticulum

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR046346 Aminoacid_DH-like_N_sf
IPR006095 Glu/Leu/Phe/Val/Trp_DH
IPR006096 Glu/Leu/Phe/Val/Trp_DH_C
IPR006097 Glu/Leu/Phe/Val/Trp_DH_dimer
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
The S-nitrosylation sites of P26443
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 112 VRGILRIIKP C NHVLSLSFPI  CCCHHHHHHH H HCCCHHHHCH  4.7% 22178444
20925432
21278135
2 172 KALASLMTYK C AVVDVPFGGA  CCCHHHHHHH H HCCCHHHHCH  2.15% 22178444
24895380
21278135
3 254 IGHYDINAHA C VTGKPISQGG  CCCHHHHHHH H HCCCHHHHCH  1.7% 22178444
4 327 MRYLHRFGAK C VGVGESDGSI  CCCHHHHHHH H HCCCHHHHCH  2.97% 24895380
22588120
21278135
5 376 VYEGSILEAD C DILIPAASEK  CCCHHHHHHH H HCCCHHHHCH  4.52% 22588120