Protein Name:
Interferon-induced transmembrane protein 3
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UniprotKB/SwissProt ID: P26376 (P26376)
Gene Name:
ifitm3
Organism: Rattus norvegicus (Rat)
Function: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Late endosome membrane. Early endosome membrane. Lysosome membrane. Cytoplasm, perinuclear region
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Graphical Visualization of S-nitrosylation Sites:
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