Protein Name:
Probable ATP-dependent RNA helicase DDX6
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UniprotKB/SwissProt ID: P26196 (P26196)
Gene Name:
DDX6
Organism: Homo sapiens (Human)
Function: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817). Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281). In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, P-body. Cytoplasm. Nucleus. Cytoplasm, Cytoplasmic ribonucleoprotein granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P26196
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
102 |
STKGNEFEDY C LKRELLMGIF |
CCCCCCCCCE E EEEECCCCCC |
5.82% |
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| 2 |
324 |
AYVTERQKVH C LNTLFSRLQI |
CCCCCCCCCE E EEEECCCCCC |
3.34% |
19483679
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| 3 |
341 |
RLQINQSIIF C NSSQRVELLA |
CCCCCCCCCE E EEEECCCCCC |
3.21% |
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| 4 |
390 |
FRNGLCRNLV C TDLFTRGIDI |
CCCCCCCCCE E EEEECCCCCC |
2.49% |
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