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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Talin-1
UniprotKB/SwissProt ID: P26039 (P26039)

Gene Name: Tln1

Organism: Mus musculus (Mouse)

Function: High molecular weight cytoskeletal protein concentrated at regions of cell-matrix and cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane. With KANK1 co-organize the assembly of cortical microtubule stabilizing complexes (CMSCs) positioned to control microtubule-actin crosstalk at focal adhesions (FAs) rims

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell surface. Cell junction, focal adhesion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR036723 Alpha-catenin/vinculin-like_sf
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR032425 FERM_f0
IPR035964 I/LWEQ_dom_sf
IPR002558 ILWEQ_dom
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR037438 Talin1/2-RS
IPR015224 Talin_cent
IPR036476 Talin_cent_sf
IPR054082 Talin_IBS2B
IPR049108 Talin_R4
IPR054060 TLN1-like_RS
IPR029071 Ubiquitin-like_domsf
IPR015009 Vinculin-bd_dom
The S-nitrosylation sites of P26039
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1023 DQASAMQLSQ C AKNLGTALAE  CCEEEEEEEE C CCEECCCCCC  5.38%
2 1045 RTAAQKAQEA C GPLEMDSALS  CCEEEEEEEE C CCEECCCCCC  5.92%
3 1199 AKAVTQALNR C VSCLPGQRDV  CCEEEEEEEE C CCEECCCCCC  2.28% 20925432
4 1353 TDSINQLITM C TQQAPGQKEC  CCEEEEEEEE C CCEECCCCCC  2.02%
5 1478 ARANQAIQMA C QSLGEPGCTQ  CCEEEEEEEE C CCEECCCCCC  2.07%
6 1661 MRDKAPGQLE C ETAIAALNSC  CCEEEEEEEE C CCEECCCCCC  8.39% 20925432
7 1927 KHRVQELGHG C SALVTKAGAL  CCEEEEEEEE C CCEECCCCCC  1.46%
8 1939 ALVTKAGALQ C SPSDVYTKKE  CCEEEEEEEE C CCEECCCCCC  7.22%
9 1953 DVYTKKELIE C ARRVSEKVSH  CCEEEEEEEE C CCEECCCCCC  2.57%
10 2219 RRAIADMLRA C KEAAFHPEVA  CCEEEEEEEE C CCEECCCCCC  3.11%
11 236 GSHPVSFDKA C EFAGFQCQIQ  CCEEEEEEEE C CCEECCCCCC  5.64%
12 2408 RMVAAATNNL C EAANAAVQGH  CCEEEEEEEE C CCEECCCCCC  3.48% 20925432
13 2442 AASTAQLLVA C KVKADQDSEA  CCEEEEEEEE C CCEECCCCCC  3.97%
14 286 ERKIFQAHKN C GQMSEIEAKV  CCEEEEEEEE C CCEECCCCCC  4.83% 21278135
15 709 QTQVIAAATQ C ALSTSQLVAC  CCEEEEEEEE C CCEECCCCCC  3.41%
16 719 CALSTSQLVA C TKVVAPTISS  CCEEEEEEEE C CCEECCCCCC  2.7%
17 732 VVAPTISSPV C QEQLVEAGRL  CCEEEEEEEE C CCEECCCCCC  4.12%
18 956 AGPQPLLVQS C KAVAEQIPLL  CCEEEEEEEE C CCEECCCCCC  1.51%