Protein Name:
Tumor necrosis factor receptor superfamily member 6
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UniprotKB/SwissProt ID: P25445 (P25445)
Gene Name:
FAS
Organism: Homo sapiens (Human)
Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane raft. Secreted. Secreted. Secreted. Secreted. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P25445
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
199 |
WVKRKEVQKT C RKHRKENQGS |
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| 2 |
304 |
LIKDLKKANL C TLAEKIQTII |
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