Protein Name:
DNA replication licensing factor MCM3
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UniprotKB/SwissProt ID: P25205 (P25205)
Gene Name:
MCM3
Organism: Homo sapiens (Human)
Function: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P25205
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
134 |
VVCVEGIVTK C SLVRPKVVRS |
CCCEEEECHH H HHHHHHHHHH |
2.51% |
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| 2 |
148 |
RPKVVRSVHY C PATKKTIERR |
CCCEEEECHH H HHHHHHHHHH |
0.82% |
19483679
2212679
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| 3 |
243 |
DRVQVVGTYR C LPGKKGGYTS |
CCCEEEECHH H HHHHHHHHHH |
3.66% |
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| 4 |
263 |
SGTFRTVLIA C NVKQMSKDAQ |
CCCEEEECHH H HHHHHHHHHH |
4.82% |
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| 5 |
319 |
GHDYVKKAIL C LLLGGVERDL |
CCCEEEECHH H HHHHHHHHHH |
1.74% |
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| 6 |
360 |
AKSQLLRYVL C TAPRAIPTTG |
CCCEEEECHH H HHHHHHHHHH |
1.86% |
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| 7 |
407 |
AMVLADRGVV C IDEFDKMSDM |
CCCEEEECHH H HHHHHHHHHH |
2.78% |
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| 8 |
446 |
AGIHARLNAR C SVLAAANPVY |
CCCEEEECHH H HHHHHHHHHH |
2.83% |
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