Protein Name:
Acetyl-CoA acetyltransferase, mitochondrial
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UniprotKB/SwissProt ID: P24752 (P24752)
Gene Name:
ACAT1
Organism: Homo sapiens (Human)
Function: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (PubMed:1715688, PubMed:7728148, PubMed:9744475). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (PubMed:1715688, PubMed:7728148, PubMed:9744475). The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA (PubMed:17371050). Thereby, it plays a major role in ketone body metabolism (PubMed:1715688, PubMed:17371050, PubMed:7728148, PubMed:9744475)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P24752
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
119 |
LGAGLPISTP C TTINKVCASG |
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| 2 |
126 |
STPCTTINKV C ASGMKAIMMA |
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| 3 |
196 |
DVYNKIHMGS C AENTAKKLNI |
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| 4 |
413 |
KQGEYGLASI C NGGGGASAML |
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