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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ribonucleoside-diphosphate reductase large subunit

UniprotKB/SwissProt ID: P23921 (P23921)

Gene Name: RRM1

Organism: Homo sapiens (Human)

Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR005144 ATP-cone_dom
IPR013346 NrdE_NrdA_C
IPR000788 RNR_lg_C
IPR013509 RNR_lsu_N
IPR008926 RNR_R1-su_N
IPR039718 Rrm1

The S-nitrosylation sites of P23921

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 238 IEGIYDTLKQ C ALISKSAGGI   
2 254 SAGGIGVAVS C IRATGSYIAG   
3 26 DKITSRIQKL C YGLNMDFVDP   
4 356 QDWSLMCPNE C PGLDEVWGEE   
5 425 SNQQNLGTIK C SNLCTEIVEY   
6 444 EYTSKDEVAV C NLASLALNMY   
7 492 DINYYPVPEA C LSNKRHRPIG   
8 544 TIYYGALEAS C DLAKEQGPYE   
9 662 HEEMKNQIIA C NGSIQSIPEI   
10 779 EKERNTAAMV C SLENRDECLM