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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Thymidylate kinase

UniprotKB/SwissProt ID: P23919 (P23919)

Gene Name: DTYMK

Organism: Homo sapiens (Human)

Function: Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR027417 P-loop_NTPase
IPR039430 Thymidylate_kin-like_dom
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase

The S-nitrosylation sites of P23919

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 117 GAKENFSLDW C KQPDVGLPKP  CCCCCCCEEE E ECCCCCCCCH  2.68%
2 31 TQSRKLVEAL C AAGHRAELLR  CCCCCCCEEE E ECCCCCCCCH  2.92% 22178444
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