Protein Name:
Colorectal mutant cancer protein
|
UniprotKB/SwissProt ID: P23508 (P23508)
Gene Name:
MCC
Organism: Homo sapiens (Human)
Function: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P23508
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
58 |
LLEKKLAKAQ C EQSHLMREHE |
CCCCCCCCCC C CCHHHHHHHH |
6.5% |
24105792
|
| 2 |
697 |
SGSKDKPGKE C ADAASPALSL |
CCCCCCCCCC C CCHHHHHHHH |
4.78% |
|
|
