Protein Name:
Tryptophan--tRNA ligase, cytoplasmic
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UniprotKB/SwissProt ID: P23381 (P23381)
Gene Name:
WARS1
Organism: Homo sapiens (Human)
Function: Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp) Has no angiostatic activity Possesses an angiostatic activity but has no aminoacylation activity (PubMed:11773625, PubMed:11773626, PubMed:14630953). Inhibits fluid shear stress-activated responses of endothelial cells (PubMed:14630953). Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (PubMed:14630953) Has an angiostatic activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P23381
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
225 |
AVENAKDIIA C GFDINKTFIF |
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| 2 |
274 |
KGIFGFTDSD C IGKISFPAIQ |
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| 3 |
309 |
DRTDIQCLIP C AIDQDPYFRM |
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| 4 |
62 |
AAAGEDYKAD C PPGNPAPTSN |
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