Protein Name:
Gap junction alpha-1 protein
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UniprotKB/SwissProt ID: P23242 (P23242)
Gene Name:
Gja1
Organism: Mus musculus (Mouse)
Function: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Plays an essential role in gap junction communication in the ventricles (PubMed:26403541) Connexin 43 is possibly the ATP-induced pore of mouse macrophages
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell junction, gap junction. Endoplasmic reticulum
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P23242
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
260 |
TTGPLSPSKD C GSPKYAYFNG |
CCCHHHHHHH H HHHHHHHCCC |
7.17% |
21278135
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| 2 |
271 |
GSPKYAYFNG C SSPTAPLSPM |
CCCHHHHHHH H HHHHHHHCCC |
3.69% |
21071693
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| 3 |
298 |
LVTGDRNNSS C RNYNKQASEQ |
CCCHHHHHHH H HHHHHHHCCC |
3.08% |
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