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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Integrin alpha-6
UniprotKB/SwissProt ID: P23229 (P23229)

Gene Name: ITGA6

Organism: Homo sapiens (Human)

Function: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR018184 Integrin_alpha_C_CS
IPR013649 Integrin_alpha_Ig-like_1
IPR048285 Integrin_alpha_Ig-like_2
IPR048286 Integrin_alpha_Ig-like_3
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
The S-nitrosylation sites of P23229
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 131 SQGPGGKVVT C AHRYEKRQHV  CCHHHHHHHH H HHHHHHHHHH  1.71% 22178444
20140087
2 541 PSGICLQVKS C FEYTANPAGY  CCHHHHHHHH H HHHHHHHHHH  2.2% 22178444
20140087
3 86 RANRTGGLYS C DITARGPCTR  CCHHHHHHHH H HHHHHHHHHH  2.5% 22178444
20140087