UniprotKB/SwissProt ID: P23188 (P23188)
Gene Name:
Furin
Organism: Mus musculus (Mouse)
Function: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:18713856). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-45) (By similarity). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (PubMed:18713856)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, trans-Golgi network membrane. Cell membrane. Secreted. Endosome membrane
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