Protein Name:
Eukaryotic translation initiation factor 3 subunit A
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UniprotKB/SwissProt ID: P23116 (P23116)
Gene Name:
Eif3a
Organism: Mus musculus (Mouse)
Function: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P23116
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
185 |
HDIAQQAFKF C LQYTRKAEFR |
CCCCCCCHHH H HHHHHHHHHH |
2.09% |
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| 2 |
478 |
ERAIVDAARH C DLQVRIDHTS |
CCCCCCCHHH H HHHHHHHHHH |
4.68% |
20925432
21278135
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| 3 |
78 |
KEGLYQYKNI C QQVNIKSLED |
CCCCCCCHHH H HHHHHHHHHH |
3.02% |
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