Protein Name:
Nucleoside diphosphate kinase B
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UniprotKB/SwissProt ID: P22392 (P22392)
Gene Name:
NME2
Organism: Homo sapiens (Human)
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:19435876, PubMed:8392752). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P22392
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
109 |
SKPGTIRGDF C IQVGRNIIHG |
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37478858
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| 2 |
145 |
KPEELVDYKS C AHDWVYE--- |
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