Protein Name:
Ubiquitin-like modifier-activating enzyme 1
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UniprotKB/SwissProt ID: P22314 (P22314)
Gene Name:
UBA1
Organism: Homo sapiens (Human)
Function: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1447181, PubMed:1606621, PubMed:33108101). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Mitochondrion. Nucleus. Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P22314
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1039 |
RHVRALVLEL C CNDESGEDVE |
CCCCCCCCCC C CCCCCCCCCC |
1.17% |
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| 2 |
1040 |
HVRALVLELC C NDESGEDVEV |
CCCCCCCCCC C CCCCCCCCCC |
12.9% |
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| 3 |
179 |
LEDQLRVGEF C HNRGIKLVVA |
CCCCCCCCCC C CCCCCCCCCC |
2.12% |
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| 4 |
200 |
DTRGLFGQLF C DFGEEMILTD |
CCCCCCCCCC C CCCCCCCCCC |
6.03% |
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| 5 |
234 |
VTKDNPGVVT C LDEARHGFES |
CCCCCCCCCC C CCCCCCCCCC |
2.81% |
22178444
20140087
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| 6 |
278 |
KVLGPYTFSI C DTSNFSDYIR |
CCCCCCCCCC C CCCCCCCCCC |
4.53% |
37478858
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| 7 |
481 |
YFLVGAGAIG C ELLKNFAMIG |
CCCCCCCCCC C CCCCCCCCCC |
2.45% |
37478858
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| 8 |
494 |
LKNFAMIGLG C GEGGEIIVTD |
CCCCCCCCCC C CCCCCCCCCC |
5.58% |
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| 9 |
588 |
VDARMYMDRR C VYYRKPLLES |
CCCCCCCCCC C CCCCCCCCCC |
2.1% |
37478858
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| 10 |
632 |
QDPPEKSIPI C TLKNFPNAIE |
CCCCCCCCCC C CCCCCCCCCC |
2.82% |
19483679
37478858
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| 11 |
906 |
TTTAAVVGLV C LELYKVVQGH |
CCCCCCCCCC C CCCCCCCCCC |
2.69% |
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