Protein Name:
Oxysterol-binding protein 1
|
UniprotKB/SwissProt ID: P22059 (P22059)
Gene Name:
OSBP
Organism: Homo sapiens (Human)
Function: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P22059
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
224 |
LSSKVEDLST C NDLIAKHGTA |
|
|
|
| 2 |
343 |
PGNVGSGKDQ C CSGKGDMSDE |
|
|
|
| 3 |
517 |
RLEENGYRSL C EQVSHHPPAA |
|
|
|
| 4 |
794 |
THIYRGEYWE C KEKQDWSSCP |
|
|
|
| 5 |
803 |
ECKEKQDWSS C PDIF------ |
|
|
|
|
