Protein Name:
Receptor tyrosine-protein kinase erbB-3
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UniprotKB/SwissProt ID: P21860 (P21860)
Gene Name:
ERBB3
Organism: Homo sapiens (Human)
Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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